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Synthesis and properties of water-soluble 1,9-dialkyl-substituted BF

Dan Wu, Gonzalo Durán-Sampedro, Donal F. O’Shea

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 1,   Pages 97-104 doi: 10.1007/s11705-019-1828-x

Abstract: Both fluorophores exhibited excellent near-infrared (NIR) photophysical properties in methanol and aqueousLive cell microscopy imaging revealed efficient uptake and intracellular labelling of cells for bothTheir simple synthesis, with potential for last-step structural modifications, makes the present NIR-activeazadipyrromethene derivatives potentially useful as NIR fluorescence imaging probes for live cells.

Keywords： NIR-fluorophores     live cell imaging     NIR-AZA    

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Near-infrared fluorescent probe for fast track of cyclooxygenase-2 in Golgi apparatus in cancer cells

Bhaskar Gurram, Miao Li, Jiangli Fan, Jingyun Wang, Xiaojun Peng

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 1,   Pages 41-52 doi: 10.1007/s11705-019-1796-1

Abstract: Tumor tissue (depth: 500 µm), organs and mice imaging tests show excellent near-infrared visualization

Keywords： cyclooxygenase-2     nile blue     CCB     Golgi apparatus     NIR imaging    

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Structural and Functional NIR-II Fluorescence Bioimaging in Urinary System via Clinically Approved Dye Article

Dingwei Xue,Di Wu,Zeyi Lu,Jochen Neuhaus,Abudureheman Zebibula,Zhe Feng,Sheng Cheng,Jing Zhou,Jun Qian,Gonghui Li

Engineering 2023, Volume 22, Issue 3,   Pages 149-158 doi: 10.1016/j.eng.2021.07.032

Abstract:

Accurate structural and functional imaging is vital for the diagnosis and prognosis of urinary systemFluorescence bioimaging in the second near-infrared spectral region (NIR-II, 1000–1700 nm)Herein, we first report in vivo NIR-II fluorescence imaging of the urinary system enabled by a clinicallyThese results demonstrate that MB assisted NIR-II fluorescence imaging holds a great promise for structuraland functional imaging of the urinary system both clinically and preclinically.

Keywords： NIR-II fluorescence     Methylene blue     Renal function     Urinary system     Real-time imaging    

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evaluation of renal function using diffusion weighted imaging and diffusion tensor imaging in type 2

Xiaoyan Chen,Wenxia Xiao,Xinchun Li,Jianxun He,Xiaochun Huang,Yuyu Tan

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 471-476 doi: 10.1007/s11684-014-0365-8

Abstract:

This work aims to estimate the value of diffusion weighted imaging (DWI) and diffusion tensor imaging

Keywords： type 2 diabetes mellitus     microalbuminuria     diffusion weighted imaging     diffusion tensor imaging     early-stage    

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Carbon dots-based fluorescence sensor for two-photon imaging of pH in diabetic mice

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 3,   Pages 298-306 doi: 10.1007/s11705-022-2212-9

Abstract: Finally, the CA-CDs has been successfully applied for two-photon imaging of the pH in liver and kidneyImaging results showed that the pH value in kidney of diabetic mice was lower than that of the normal

Keywords： carbon dots     two-photon imaging     pH     diabetic mice    

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In vivo imaging of hematopoietic stem cell development in the zebrafish

Panpan Zhang, Feng Liu

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 239-247 doi: 10.1007/s11684-011-0123-0

Abstract: imaging is crucial for developmental biology and can further help to follow cell development/differentiationRecent advances in optical imaging techniques has facilitated tracing of the developmental dynamics ofThe zebrafish is an excellent model for imaging of hematopoiesis due to its transparent embryo at earlyIn this review, we summarize recent studies related to the non-invasive imaging of HSC transgenics,

Keywords： hematopoietic stem cell     hematopoiesis     in vivo imaging     transgenics     zebrafish    

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Anefficient quadrature demodulator for medical ultrasound imaging

Hao ZHOU,Yin-fei ZHENG

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 4,   Pages 301-310 doi: 10.1631/FITEE.1400205

Abstract: Quadrature demodulation is used in medical ultrasound imaging to derive the envelope and instantaneousIn this paper, we propose an efficient quadrature demodulation method for B-mode and color flow imagingIn the in vivo color flow imaging experiments, the time of the demodulation process was 5.66 ms and 3.36

Keywords： B-mode ultrasound imaging     Color flow imaging     Quadrature demodulation     Finite impulse response filter    

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Light field imaging: models, calibrations, reconstructions,and applications Review

Hao ZHU, Qing WANG, Jingyi YU

Frontiers of Information Technology & Electronic Engineering 2017, Volume 18, Issue 9,   Pages 1236-1249 doi: 10.1631/FITEE.1601727

Abstract: Light field imaging is an emerging technology in computationalphotography areas.Based on innovative designs of the imaging modeland the optical path, light field cameras not only recordFinally,open issues in light field imaging and long-term application prospectsin other natural sciences

Keywords： Light field imaging     Plenoptic function     Imaging model     Calibration     Reconstruction    

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Inhibition of FLT3: A Prototype for Molecular Targeted Therapy in Acute Myeloid Leukemia Review

Rowe, Nir Weigert

Engineering 2021, Volume 7, Issue 10,   Pages 1354-1368 doi: 10.1016/j.eng.2021.05.020

Abstract:

Modern therapy of acute myeloid leukemia (AML) began in 1973 with the first report of the successful combination of daunorubicin and cytarabine, which led to complete remission in approximately 45% of patients. Accurate AML diagnosis was dependent on morphology, aided initially only by cytochemistry. Unlike acute lymphoblastic leukemia (ALL), immunophenotyping offered little in the diagnosis of AML, at least during the 1970s and 1980s. The advent of reliable cytogenetics changed the entire prognostic outlook of AML. With karyotypic analysis, different groups of AML could be classified and stratified for various therapies. Unique mutational profiling was a major advance in further categorizing AML patients, aided by the immunophenotypic identification of antigenic markers on the cells. All these advances were occurring as the understanding of the importance of the tumor burden—known as minimal residual disease (MRD)—became crucial for the management of AML patients. The efficacy of MRD has rapidly progressed in the past decade, from a specificity of 10−3 with immunophenotyping to 10−4 with polymerase chain reaction (PCR), which is only appropriate for some patients with AML, and finally to 10−5 or even 10−6 cells with the extraordinary sensitivity of next-generation sequencing (NGS). All of these advances have promoted the concept of personalized medicine, which has led to the advent of targeted agents that can accurately be used for specific diagnostic subtypes. Responses can be predicted and measured accurately. Such targeted agents have now become a cornerstone in the management of AML, increasing efficacy and dramatically reducing toxicity. The focus of this review is on one of the most well-studied targeted agents in AML: the FMS-like tyrosine kinase 3 (FLT3) inhibitors, which have impacted the prognostication and therapeutics of AML. This review selectively discusses the FLT3 inhibitors in detail, as a model for the other burgeoning targeted agents that have already been approved, as well as those that are currently in development.

Keywords： AMLTargeted therapy     FLT3 inhibitors     Midostaurin     Gilteritinib     Quizartinib     Sorafenib    

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Synthesis and application of superparamagnetic iron oxide nanoparticles in targeted therapy and imaging

Liangqian Tong, Ming Zhao, Shu Zhu, Jing Chen

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 379-387 doi: 10.1007/s11684-011-0162-6

Abstract: Superparamagnetic iron oxide (SPIO) nanoparticles have become a popular strategy of cancer treatment and molecular imaging, targeted ligand-conjugated, and/or drug-loaded SPIO nanoparticles, as powerful tools for targeted imagingadvancements in the field of SPIO nanoparticles in terms of synthesis, targeted therapy, and cancer imaging

Keywords： nanoparticles     superparamagnetic iron oxide     targeted therapy     molecular imaging     cancer    

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A highly selective fluorescent probe for real-time imaging of UDP-glucuronosyltransferase 1A8 in living

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 103-111 doi: 10.1007/s11705-021-2064-8

Abstract: Uridine diphosphate (UDP)-glucuronosyltransferases (UGTs) are enzymes involved in the biotransformation of important endogenous compounds such as steroids, bile acids, and hormones as well as exogenous substances including drugs, environmental toxicants, and carcinogens. Here, a novel fluorescent probe BDMP was developed based on boron-dipyrromethene (BODIPY) with high sensitivity for the detection of UGT1A8. The glucuronidation of BDMP not only exhibited a red-emission wavelength (λex/λem = 500/580 nm), but also displayed an excellent UGT1A8-dependent fluorescence signal with a good linear relationship with UGT1A8 concentration. Based on this perfect biocompatibility and cell permeability, BDMP was successfully used to image endogenous UGT1A8 in human cancer cell lines (LoVo and HCT15) in real time. In addition, BDMP could also be used to visualize UGT1A8 in tumor tissues. These results suggested that BDMP is a promising molecular tool for the investigation of UGT1A8-mediated physiological function in humans.

Keywords： UDP-glucuronosyltransferase 1A8     fluorescent probe     subtype selectivity     fluorescence imaging    

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of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic resonance imaging

Frontiers of Medicine   Pages 993-1005 doi: 10.1007/s11684-023-0989-7

Abstract: The functional magnetic resonance imaging (fMRI) data were analyzed for investigating brain changes induced

Keywords： acupuncture     migraine     fMRI     metabolome     proteome    

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Iron oxide nanoparticle-based theranostics for cancer imaging and therapy

Xiaoqing REN,Hongwei CHEN,Victor YANG,Duxin SUN

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 3,   Pages 253-264 doi: 10.1007/s11705-014-1425-y

Abstract: studied, iron oxide nanoparticles have advantages since IONPs have good biocompatibility and spatial imagingThis review is focused on the IONP-based nanotheranostics for cancer imaging and treatment.applications of IONP nanotheranostics is summarized, which includes IONP-based diagnosis, magnetic resonance imaging(MRI), multimodal imaging, chemotherapy, hyperthermal therapy, photodynamic therapy, and gene delivery

Keywords： theranostics     iron oxide nanoparticles     MRI     drug delivery     photothermal therapy     photodynamic therapy    

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High resolution satellite imaging sensors for precision agriculture

Chenghai YANG

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 4,   Pages 393-405 doi: 10.15302/J-FASE-2018226

Abstract: These imaging sensors not only provide images with high spatial resolution, but can also repeatedly view

Keywords： high resolution satellite sensor     multispectral imagery     precision agriculture     spatial resolution     temporal resolution    

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Transient imaging with a time-of-flight cameraand its applications

Jing-yu LIN, Ri-hui WU, Hong-man WANG, Ye-bin LIU

Frontiers of Information Technology & Electronic Engineering 2017, Volume 18, Issue 9,   Pages 1268-1276 doi: .org/10.1631/FITEE.1700556

Abstract: Transient imaging is a technique in photography that recordsthe process of light propagation before itIn thisreview we introduce three main models for transient imaging with atime-of-flight (ToF) camera:Transient imaging applications usuallyinvolve resolving the problem of light transport and separatingWe discuss two of the applications:imaging objects inside scattering media and recovering both the shapeand

Keywords： Transient imaging     Time-of-flight(ToF) camera     Scattering media     Around corners    

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Title Author Date Type Operation

Synthesis and properties of water-soluble 1,9-dialkyl-substituted BF

Dan Wu, Gonzalo Durán-Sampedro, Donal F. O’Shea

Journal Article

Near-infrared fluorescent probe for fast track of cyclooxygenase-2 in Golgi apparatus in cancer cells

Bhaskar Gurram, Miao Li, Jiangli Fan, Jingyun Wang, Xiaojun Peng

Journal Article

Structural and Functional NIR-II Fluorescence Bioimaging in Urinary System via Clinically Approved Dye

Dingwei Xue,Di Wu,Zeyi Lu,Jochen Neuhaus,Abudureheman Zebibula,Zhe Feng,Sheng Cheng,Jing Zhou,Jun Qian,Gonghui Li

Journal Article

evaluation of renal function using diffusion weighted imaging and diffusion tensor imaging in type 2

Xiaoyan Chen,Wenxia Xiao,Xinchun Li,Jianxun He,Xiaochun Huang,Yuyu Tan

Journal Article

Carbon dots-based fluorescence sensor for two-photon imaging of pH in diabetic mice

Journal Article

In vivo imaging of hematopoietic stem cell development in the zebrafish

Panpan Zhang, Feng Liu

Journal Article

Anefficient quadrature demodulator for medical ultrasound imaging

Hao ZHOU,Yin-fei ZHENG

Journal Article

Light field imaging: models, calibrations, reconstructions,and applications

Hao ZHU, Qing WANG, Jingyi YU

Journal Article

Inhibition of FLT3: A Prototype for Molecular Targeted Therapy in Acute Myeloid Leukemia

Rowe, Nir Weigert

Journal Article

Synthesis and application of superparamagnetic iron oxide nanoparticles in targeted therapy and imaging

Liangqian Tong, Ming Zhao, Shu Zhu, Jing Chen

Journal Article

A highly selective fluorescent probe for real-time imaging of UDP-glucuronosyltransferase 1A8 in living

Journal Article

of the mechanisms of acupuncture in the treatment of migraine based on functional magnetic resonance imaging

Journal Article

Iron oxide nanoparticle-based theranostics for cancer imaging and therapy

Xiaoqing REN,Hongwei CHEN,Victor YANG,Duxin SUN

Journal Article

High resolution satellite imaging sensors for precision agriculture

Chenghai YANG

Journal Article

Transient imaging with a time-of-flight cameraand its applications

Jing-yu LIN, Ri-hui WU, Hong-man WANG, Ye-bin LIU

Journal Article